Plectin is a multi-faceted, 500 kDa-large protein, which due to its expression in different isoforms and distinct organs acts diversely as a cytoskeletal crosslinker and signaling scaffold.It functions as a mediator of keratinocyte mechanical stability in the skin, primarily through linking BOW TIE intermediate filaments to hemidesmosomes.Skin frag
Summary: CHLOROFRESH How chromosome organization is related to genome function remains poorly understood.Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene expression.Here, we examine chromosome conformation in embryonic stem cells lacking cohesin and find,
The highly pathogenic avian influenza A virus subtype H5N1 (HPAI H5N1) is a deadly zoonotic pathogen.Its persistence in poultry in several countries is a potential threat: a mutant or genetically reassorted progenitor might cause a human pandemic.Its world-wide eradication from poultry is important to protect public health.The global trend of outbr